Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176783 | 0.93 | MAPK14 (0.50) | MAPK14P2RX7CSNK1DCSNK1ESRC | |
| SCHEMBL4330915 | 0.92 | MAPK14 (0.48) | MAPK14P2RX7SRCBRAFKDR | |
| SCHEMBL6177522 | 0.91 | MAPK14 (0.50) | MAPK14P2RX7CSNK1DCSNK1ESRC | |
| SCHEMBL6178911 | 0.91 | MAPK14 (0.48) | MAPK14P2RX7CSNK1DCSNK1ESRC | |
| SCHEMBL4343517 | 0.90 | MAPK14 (0.56) | MAPK14CSNK1A1CSNK1DCSNK1ESRC | |
| SCHEMBL6176462 | 0.88 | MAPK14 (0.46) | MAPK14P2RX7SRCBRAFKDR | |
| SCHEMBL6176304 | 0.88 | MAPK14 (0.46) | MAPK14P2RX7CSNK1DCSNK1ESRC | |
| SCHEMBL4338017 | 0.88 | MAPK14 (0.55) | MAPK14CSNK1DCSNK1EEGFRKDM4E | |
| SCHEMBL6178358 | 0.87 | P2RX7 (0.46) | MAPK14P2RX7NAMPT | |
| SCHEMBL6177910 | 0.87 | MAPK14 (0.50) | MAPK14CSNK1DCSNK1ESRCBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |