Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | RORA | P35398 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177628 | 0.87 | MAPK14 (0.77) | MAPK14ALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL6176676 | 0.86 | MAPK14 (0.76) | MAPK14ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL6175320 | 0.85 | MAPK14 (0.74) | MAPK14KMT2AMEN1RORCRAB9A | |
| SCHEMBL6193971 | 0.84 | MAPK14 (0.72) | MAPK14KMT2AMEN1CYP2C19SMN1; SMN2 | |
| SCHEMBL6178969 | 0.84 | MAPK14 (0.75) | MAPK14ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL6177800 | 0.83 | MAPK14 (1.00) | MAPK14ALDH1A1POLB | |
| SCHEMBL4331508 | 0.83 | MAPK14 (0.48) | MAPK14ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL6178962 | 0.82 | MAPK14 (0.89) | MAPK14KMT2A | |
| SCHEMBL6180514 | 0.82 | MAPK14 (0.89) | MAPK14ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL6176666 | 0.81 | MAPK14 (0.76) | MAPK14ALDH1A1KMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |