Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178962 | 0.91 | MAPK14 (0.89) | MAPK14KMT2ACDK2PRKACAROCK1 | |
| SCHEMBL6180514 | 0.89 | MAPK14 (0.89) | MAPK14ALDH1A1MEN1KMT2AMAPK13 | |
| SCHEMBL6178004 | 0.87 | MAPK14 (0.82) | MAPK14ALDH1A1MAPTKMT2AMAPK1 | |
| SCHEMBL6176420 | 0.86 | MAPK14 (0.81) | MAPK14ALDH1A1MAPTKMT2ATP53 | |
| SCHEMBL6179153 | 0.86 | MAPK14 (0.81) | MAPK14KMT2AMAPK13ALOX5MAPK12 | |
| SCHEMBL6179313 | 0.86 | MAPK14 (0.81) | MAPK14KMT2AMAPK13LMNARAB9A | |
| SCHEMBL6177800 | 0.86 | MAPK14 (1.00) | MAPK14ALDH1A1MAPK13MAPK12MAPK11 | |
| SCHEMBL6177353 | 0.85 | MAPK14 (0.79) | MAPK14KMT2ATP53CDK2PRKACA | |
| SCHEMBL6177710 | 0.84 | MAPK14 (0.78) | MAPK14ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL6178765 | 0.84 | MAPK14 (0.71) | MAPK14ALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |