Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180478 | 0.88 | MAPK14 (0.60) | MAPK14MEN1KMT2AMAPTPRKACA | |
| SCHEMBL6177703 | 0.86 | MAPK14 (0.55) | MAPK14ALDH1A1MEN1KMT2APRKACA | |
| SCHEMBL6180582 | 0.86 | MAPK14 (0.57) | MAPK14SRCBRAFKDRMAPT | |
| SCHEMBL6174869 | 0.86 | MAPK14 (0.57) | MAPK14MAPTPRKACAROCK1 | |
| SCHEMBL6177480 | 0.85 | SRC (0.46) | MAPK14SRCBRAFKDRTHRB | |
| SCHEMBL4343331 | 0.85 | MAPK14 (0.71) | MAPK14SRCBRAFKDRMAPT | |
| SCHEMBL6178834 | 0.84 | MAPK14 (0.55) | MAPK14SRCBRAFKDRMEN1 | |
| SCHEMBL6179169 | 0.84 | MAPK14 (0.63) | MAPK14KMT2AGAAMAPTPRKACA | |
| SCHEMBL6176832 | 0.84 | MAPK14 (0.63) | MAPK14MAPTPRKACAROCK1 | |
| SCHEMBL4337064 | 0.83 | MAPK14 (0.57) | MAPK14MAPTPRKACAROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |