Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.38 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176783 | 0.89 | MAPK14 (0.50) | SRCBRAFKDRMAPK14P2RX7 | |
| SCHEMBL4330915 | 0.88 | MAPK14 (0.48) | SRCBRAFKDRMAPK14P2RX7 | |
| SCHEMBL6178635 | 0.87 | MAPK14 (0.48) | SRCBRAFKDRMAPK14P2RX7 | |
| SCHEMBL6178911 | 0.87 | MAPK14 (0.48) | SRCBRAFKDRMAPK14P2RX7 | |
| SCHEMBL6177522 | 0.87 | MAPK14 (0.50) | SRCBRAFKDRMAPK14P2RX7 | |
| SCHEMBL6179322 | 0.85 | MAPK14 (0.54) | SRCBRAFKDRMAPK14ALDH1A1 | |
| SCHEMBL6176462 | 0.84 | MAPK14 (0.46) | SRCBRAFKDRMAPK14P2RX7 | |
| SCHEMBL6176304 | 0.84 | MAPK14 (0.46) | SRCBRAFKDRMAPK14P2RX7 | |
| SCHEMBL6178119 | 0.84 | MAPK14 (0.52) | SRCBRAFKDRMAPK14ALDH1A1 | |
| SCHEMBL4338017 | 0.84 | MAPK14 (0.55) | MAPK14EGFRKDM4ERAB9AMAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142890-B1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG CO LTD (JP) | 2005-08-03 | — | — | EP | disclosed |
| US-6511997-B1 | For treatment of a disease associated with tumor necrosis factor alpha, interleukin 1, interleukin 6 or cyclooxygenase II; such as irritable bowel disease | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1142890-A1 | AMINOPYRAZOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |