Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 5/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 3/20 | 0.30 |
| ▸ | HTR2C | P28335 | 3/20 | 0.30 |
| ▸ | HTR2B | P41595 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21072600 | 0.79 | CES1 (0.57) | CES1NSD2BCHEDAODNMT1 | |
| SCHEMBL18688326 | 0.73 | CES1 (0.71) | CES1NSD2BCHEDAODNMT1 | |
| SCHEMBL31728064 | 0.73 | CES1 (0.41) | CES1NSD2BCHEDAODNMT1 | |
| SCHEMBL6179037 | 0.68 | CES1 (0.55) | CES1PDE7AHTR2AHTR2CHTR2B | |
| SCHEMBL11443420 | 0.67 | CES1 (0.44) | CES1 | |
| SCHEMBL31528256 | 0.66 | CES1 (0.43) | CES1BCHENOTUM | |
| SCHEMBL2478463 | 0.66 | CES1 (0.60) | CES1NSD2BCHEDAODNMT1 | |
| SCHEMBL3726368 | 0.66 | CES1 (0.41) | CES1 | |
| SCHEMBL31727854 | 0.66 | CES1 (0.60) | CES1NSD2BCHEDAODNMT1 | |
| SCHEMBL31381684 | 0.66 | CES1 (0.41) | CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105376-B1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMA (JP) | 2005-02-09 | — | — | EP | disclosed |
| CN-1161333-C | Oxindole derivatives as growth hormone releasers | ס����ҩ��ʽ���� | 2004-08-11 | — | — | CN | disclosed |
| US-6576656-B1 | Such as 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-carbamoyl-3-hydroxy-3-(2 -chlorophenyl)oxindole; growth hormone releaser | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |
| CN-1313853-A | Oxindole derivatives as growth hormone releasers | SUMITOMO PHARMA (JP) | 2001-09-19 | — | — | CN | disclosed |
| EP-1105376-A1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010975-A1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2000-03-02 | — | — | WO | disclosed |