SCHEMBL31728064

SCHEMBL31728064

O=C1Nc2c(I)ccc(Br)c2C1=O

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CES1 P23141 12/20 0.41
ALDH1A1 P00352 2/20 0.37
ALDH2 P05091 1/20 0.37
ALDH3A1 P30838 1/20 0.37
DAO P14920 2/20 0.32
TGM2 P21980 2/20 0.32
BCHE P06276 2/20 0.32
NSD2 O96028 1/20 0.32
DNMT1 P26358 1/20 0.32
MEN1 O00255 1/20 0.31
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31
HTT P42858 1/20 0.31
KMT2A Q03164 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17265675 0.84 CES1 (0.47) CES1ALDH1A1ALDH2ALDH3A1DAO
SCHEMBL18688326 0.77 CES1 (0.71) CES1DAOTGM2BCHENSD2
SCHEMBL19210912 0.77 CES1 (0.41) CES1ALDH1A1ALDH2ALDH3A1DAO
SCHEMBL31528208 0.77 CES1 (0.71) CES1ALDH1A1ALDH2ALDH3A1DAO
SCHEMBL5230708 0.77 CES1 (0.62) CES1ALDH1A1ALDH2ALDH3A1DAO
SCHEMBL29444533 0.77 CES1 (0.41) CES1ALDH1A1ALDH2ALDH3A1DAO
SCHEMBL6179901 0.73 CES1 (0.47) CES1DAOBCHENSD2DNMT1
SCHEMBL28413118 0.70 MEN1 (0.41) ALDH1A1MEN1POLBMAPTHTT
SCHEMBL24399769 0.69 TGM2 (0.43) CES1ALDH1A1ALDH2ALDH3A1DAO
SCHEMBL30762587 0.69 CES1 (0.53) CES1ALDH1A1ALDH2ALDH3A1DAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025235874-A1 HETEROCYCLICS AS EGFR INHIBITORS SCHRÖDINGER, INC. (US) 2025-11-13 WO disclosed