Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4888033 | 0.83 | PTGS2 (0.53) | PTGS2PTGS1PDE3A | |
| SCHEMBL6180122 | 0.81 | APP (0.45) | PTGS2PTGS1PDE3A | |
| SCHEMBL1568089 | 0.78 | PTGS2 (0.45) | PTGS2PTGS1PDE3AFFAR4FFAR1 | |
| SCHEMBL1566913 | 0.78 | FFAR4 (0.45) | PTGS2PTGS1PDE3AFFAR4FFAR1 | |
| SCHEMBL4884126 | 0.77 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL9124507 | 0.77 | PTGS2 (0.76) | PTGS2PTGS1PDE3A | |
| SCHEMBL8474571 | 0.75 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL6315660 | 0.74 | PTGS2 (0.55) | PTGS2PTGS1PDE3A | |
| SCHEMBL8475019 | 0.72 | PTGS2 (0.73) | PTGS2PTGS1 | |
| SCHEMBL6309912 | 0.71 | PTGS2 (0.47) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528059-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle LLC (US) | 2005-05-04 | — | — | EP | disclosed |