Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180330 | 1.00 | TRPA1 (0.73) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6180550 | 0.87 | PSEN1 (0.63) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6177953 | 0.87 | TRPA1 (0.54) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6177949 | 0.87 | TRPA1 (0.54) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6180546 | 0.87 | PSEN1 (0.63) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6178865 | 0.85 | TRPA1 (1.00) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6178870 | 0.85 | TRPA1 (1.00) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6177808 | 0.79 | TRPA1 (0.86) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL6177006 | 0.79 | TRPA1 (0.86) | TRPA1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL3731913 | 0.79 | TRPA1 (0.86) | TRPA1LMNAPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165510-B1 | 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | disclosed |
| US-6284785-B1 | HAVING ACTIVITY AS LIGANDS OF METABOTROPIC GLUTAMATE RECEPTORS | HOFFMANN- LA ROCHE INC. | 2001-09-04 | — | — | US | disclosed |