Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.86 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.61 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.61 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.61 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.61 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.61 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180423 | 1.00 | TRPA1 (0.86) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6178865 | 0.93 | TRPA1 (1.00) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6178870 | 0.93 | TRPA1 (1.00) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6180588 | 0.90 | PSEN1 (0.74) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6180584 | 0.90 | PSEN1 (0.74) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6179785 | 0.89 | TRPA1 (0.77) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6179787 | 0.89 | TRPA1 (0.77) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6177802 | 0.86 | TRPA1 (0.64) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6177799 | 0.86 | TRPA1 (0.64) | TRPA1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3731913 | 0.86 | TRPA1 (0.86) | TRPA1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165510-B1 | 1-ARENESULFONYL-2-ARYL-PYRROLIDINE AND PIPERIDINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | disclosed |
| US-6284785-B1 | HAVING ACTIVITY AS LIGANDS OF METABOTROPIC GLUTAMATE RECEPTORS | HOFFMANN- LA ROCHE INC. | 2001-09-04 | — | — | US | disclosed |