SCHEMBL6180475

SCHEMBL6180475

Fc1ccc(CNCCc2c[nH]cn2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.50
CHRM2 P08172 1/20 0.47
MPO P05164 2/20 0.46
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA4 P22748 1/20 0.44
LTA4H P09960 1/20 0.44
EPHX2 P34913 1/20 0.44
LMNA P02545 2/20 0.43
CYP1A2 P05177 2/20 0.42
CYP2D6 P10635 2/20 0.42
CYP2C19 P33261 2/20 0.42
CYP2C9 P11712 1/20 0.42
HTR2A P28223 1/20 0.41
CYP3A4 P08684 1/20 0.40
MCHR1 Q99705 1/20 0.40
TRPV6 Q9H1D0 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6179255 0.85 CHRM2 (0.47) CHRM2KDM4ECA12CA1CA2
SCHEMBL4605920 0.84 GAA (0.53) CHRM2MPOKDM4EALDH1A1EPHX2
SCHEMBL4967965 0.81 CA12 (0.48) KDM4EALDH1A1CA12CA1CA2
Hydrochloric Acid SCHEMBL7460700 0.80 CA12 (0.47) KDM4EALDH1A1CA12CA1CA2
SCHEMBL17654953 0.80 EPHX2 (0.33) L3MBTL1CHRM2KDM4EALDH1A1EPHX2
SCHEMBL31364603 0.78 ALDH1A1 (0.31) ALDH1A1CYP1A2CYP2C19
SCHEMBL31364605 0.78 ALDH1A1 (0.31) ALDH1A1CYP1A2CYP2C19
SCHEMBL1230783 0.75
SCHEMBL28260270 0.75 HTR2C (0.40) MPOALDH1A1LMNATAAR1
SCHEMBL14197626 0.74 ROCK1 (0.41) KDM4EALDH1A1CYP1A2CYP2D6CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140909-B1 NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE SCHERING CORP (US) 2005-07-06 EP disclosed
US-6432959-B1 ANTITUMOR AGENTS SCHERING CORPORATION 2002-08-13 US disclosed
CN-1346355-A Novel inhibitors of farnesyl-protein transferase SCHERING CORP (US) 2002-04-24 CN disclosed
EP-1140909-A1 NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE SCHERING CORPORATION (US) 2001-10-10 EP disclosed
WO-2000039119-A1 NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE SCHERING CORPORATION (US) 2000-07-06 WO disclosed