Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.44 |
| ▸ | MEF2D | Q14814 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1157585 | 0.89 | PDE5A (0.54) | KMT2AMEN1GAAC5AR1HDAC4 | |
| SCHEMBL1157256 | 0.77 | UTS2R (0.57) | KMT2AMEN1GAAC5AR1HDAC4 | |
| SCHEMBL1157363 | 0.76 | POLB (0.49) | KMT2AMEN1C5AR1ALDH1A1MAPT | |
| SCHEMBL1157332 | 0.76 | PDE4A (0.58) | KMT2AMEN1C5AR1POLBPDE4D | |
| SCHEMBL21232529 | 0.76 | HDAC4 (0.60) | GAAHDAC4MEF2DALDH1A1MAPT | |
| SCHEMBL986245 | 0.71 | PDE4A (0.60) | KMT2AMEN1GAAALDH1A1MAPT | |
| SCHEMBL1157253 | 0.71 | TUBB4A (0.57) | KMT2AMEN1GAAALDH1A1MAPT | |
| SCHEMBL1157362 | 0.70 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1CPOLB | |
| SCHEMBL986248 | 0.70 | PDE4A (0.58) | PDE4D | |
| SCHEMBL1157697 | 0.70 | POLB (0.52) | KMT2AMEN1GAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539697-A1 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED ANILINE AND DIPHENYLAMINE ANALOGS | Memory Pharmaceutical Corporation (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004009552-A1 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED ANILINE AND DIPHENYLAMINE ANALOGS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |