Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMBR | P28336 | 16/20 | 0.48 |
| ▸ | GRPR | P30550 | 16/20 | 0.48 |
| ▸ | FPR1 | P21462 | 2/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179976 | 0.88 | NMBR (0.65) | NMBRGRPRFPR1AGTR1GPR65 | |
| SCHEMBL6254953 | 0.87 | NMBR (0.49) | NMBRGRPRFPR1AGTR1GPR65 | |
| SCHEMBL6917827 | 0.83 | NMBR (0.41) | NMBRGRPRFPR1AGTR1GPR65 | |
| SCHEMBL6181113 | 0.78 | NMBR (0.53) | NMBRGRPRFPR1AGTR1GPR65 | |
| SCHEMBL6251923 | 0.78 | NMBR (0.51) | NMBRGRPRFPR1AGTR1GPR65 | |
| SCHEMBL7192683 | 0.78 | NMBR (0.67) | NMBRGRPRFPR1AGTR1GPR65 | |
| SCHEMBL6250491 | 0.77 | NMBR (0.52) | NMBRGRPRFPR1AGTR1GPR65 | |
| SCHEMBL6180474 | 0.76 | NMBR (0.78) | NMBRGRPRFPR1AGTR1GPR65 | |
| SCHEMBL6184335 | 0.76 | NMBR (0.64) | NMBRGRPRFPR1AGTR1GPR65 | |
| SCHEMBL6181252 | 0.75 | NMBR (0.64) | NMBRGRPRFPR1AGTR1GPR65 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920424-B1 | NON-PEPTIDE BOMBESIN RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2005-11-30 | — | — | EP | claimed |
| US-6194437-B1 | ANTIDEPRESSANTS; ANTICANCER AGENTS; GASTROINTESTINAL DISORDERS; COGNITION ACTIVATORS | WARNER-LAMBERT COMPANY | 2001-02-27 | — | — | US | claimed |
| EP-0920424-A1 | NON-PEPTIDE BOMBESIN RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-06-09 | — | — | EP | claimed |
| WO-1998007718-A1 | NON-PEPTIDE BOMBESIN RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-02-26 | — | — | WO | claimed |
| EP-0920424-B1 | NON-PEPTIDE BOMBESIN RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2005-11-30 | — | — | EP | disclosed |