Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 4/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6483937 | 0.85 | TGFBR1 (0.40) | TGFBR1MAPK14ATMTEKMAOA | |
| SCHEMBL6178736 | 0.84 | TGFBR1 (0.38) | TGFBR1MEN1KMT2AATM | |
| SCHEMBL6183901 | 0.84 | KDM1A (0.40) | MEN1KMT2AATM | |
| SCHEMBL6183430 | 0.80 | TGFBR1 (0.41) | TGFBR1MAPK14MEN1KMT2AATM | |
| SCHEMBL6178729 | 0.78 | MEN1 (0.38) | TGFBR1MAPK14MEN1KMT2AATM | |
| SCHEMBL5138611 | 0.77 | MAPK14 (0.51) | TGFBR1MAPK14MEN1KMT2ATEK | |
| SCHEMBL6183426 | 0.69 | KMT2A (0.36) | TGFBR1MAPK14MEN1KMT2AATM | |
| SCHEMBL14086496 | 0.69 | TGFBR1 (0.52) | TGFBR1MAPK14 | |
| SCHEMBL3265486 | 0.68 | CCR1 (0.54) | TGFBR1 | |
| SCHEMBL4075747 | 0.66 | MEN1 (0.46) | TGFBR1MAPK14MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268465-B1 | TRIARYLIMIDAZOLE DERIVATIVES AS CYTOKINE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1268465-A1 | TRIARYLIMIDAZOLE DERIVATIVES AS CYTOKINE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072737-A1 | TRIARYLIMIDAZOLE DERIVATIVES AS CYTOKINE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-04 | — | — | WO | disclosed |