Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.69 |
| ▸ | CLK1 | P49759 | 1/20 | 0.69 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.69 |
| ▸ | LCK | P06239 | 7/20 | 0.67 |
| ▸ | SRC | P12931 | 1/20 | 0.66 |
| ▸ | KDR | P35968 | 6/20 | 0.64 |
| ▸ | RET | P07949 | 5/20 | 0.63 |
| ▸ | KIF5B | P33176 | 2/20 | 0.63 |
| ▸ | FLT1 | P17948 | 1/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | STK10 | O94804 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | JAK3 | P52333 | 1/20 | 0.62 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.62 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.62 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.62 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.62 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6182470 | 0.99 | EGFR (0.70) | EGFRCLK1ABCG2LCKSRC | |
| SCHEMBL5565334 | 0.93 | SRC (0.71) | EGFRCLK1ABCG2LCKSRC | |
| SCHEMBL5650428 | 0.83 | KDR (0.69) | KDR | |
| SCHEMBL5565137 | 0.82 | EGFR (1.00) | EGFRCLK1ABCG2LCKSRC | |
| SCHEMBL18292487 | 0.81 | MAPT (0.67) | EGFRSRCPDE5A | |
| SCHEMBL4378099 | 0.80 | SRC (1.00) | EGFRABCG2LCKSRCKDR | |
| SCHEMBL12308055 | 0.80 | PDE5A (0.81) | EGFRLCKSRCKDRFLT1 | |
| SCHEMBL18292469 | 0.79 | EGFR (0.68) | EGFRALK | |
| SCHEMBL18292491 | 0.79 | MAPT (0.64) | EGFRABCG2SRC | |
| SCHEMBL5565204 | 0.79 | KDR (0.79) | EGFRCLK1ABCG2LCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871448-B1 | ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS WHICH INHIBIT CSF-1R RECEPTOR TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2005-03-02 | — | — | EP | claimed |
| US-RE37650-E1 | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase | AVENTIS PHARMACETICAL PRODUCTS, INC. | 2002-04-09 | — | — | US | claimed |