Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15253247 | 0.79 | GPR119 (0.47) | GPR119PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2366151 | 0.79 | GPR119 (0.65) | GPR119PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25394031 | 0.79 | GPR119 (0.53) | GPR119PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL31078824 | 0.78 | GPR119 (0.52) | GPR119PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30740748 | 0.78 | GPR119 (0.55) | GPR119PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1364255 | 0.78 | GPR119 (0.55) | GPR119PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23121896 | 0.78 | PDE4B (0.55) | GPR119PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1892356 | 0.78 | GPR119 (0.52) | GPR119PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2591241 | 0.77 | ACACB (0.53) | GPR119PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2538047 | 0.77 | GPR119 (0.53) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0844877-B1 | USE OF OXIDO-SQUALENE CYCLASE INHIBITORS TO LOWER BLOOD CHOLESTEROL | ASTRAZENECA AB (SE) | 2005-01-26 | — | — | EP | disclosed |
| US-6090813-A | Use of oxido-squalene cyclase inhibitors to lower blood cholesterol | ZENECA LIMITED (GB) | 2000-07-18 | — | — | US | disclosed |
| EP-0844877-A1 | USE OF OXIDO-SQUALENE CYCLASE INHIBITORS TO LOWER BLOOD CHOLESTEROL | ZENECA LIMITED (GB) | 1998-06-03 | — | — | EP | disclosed |
| WO-1997006802-A1 | USE OF OXIDO-SQUALENE CYCLASE INHIBITORS TO LOWER BLOOD CHOLESTEROL | ZENECA LIMITED (GB) | 1997-02-27 | — | — | WO | disclosed |