Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.46 |
| ▸ | HTR1D | P28221 | 8/20 | 0.46 |
| ▸ | HTR1B | P28222 | 8/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180948 | 0.71 | HTR1A (0.60) | HTR1AHTR1DHTR1BHTR2CCYP1A2 | |
| SCHEMBL16647211 | 0.70 | HTR2C (0.58) | HTR1AHTR1DHTR1BHTR2CCYP1A2 | |
| SCHEMBL6179304 | 0.66 | HTR1A (0.64) | HTR1AHTR1DHTR1BHTR2CMAPT | |
| SCHEMBL6179764 | 0.66 | HTR2C (0.51) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL13170117 | 0.65 | HTR2C (0.64) | HTR2CHTR6 | |
| SCHEMBL3683092 | 0.65 | HTR2C (0.64) | HTR1AHTR2CPRKD1HTR6 | |
| SCHEMBL3676460 | 0.65 | HTR2C (0.64) | HTR1AHTR2CPRKD1LMNAHTR6 | |
| SCHEMBL2076366 | 0.65 | HTR2C (1.00) | HTR1AHTR1DHTR1BHTR2CCYP1A2 | |
| SCHEMBL30040877 | 0.65 | HTR2C (1.00) | HTR1AHTR1DHTR1BHTR2CCYP1A2 | |
| Hydrochloric Acid SCHEMBL31587078 | 0.64 | HTR2C (0.62) | HTR1AHTR2CPRKD1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239797-A1 | Isoquinoline and quinazoline derivatives having a combined 5HT1A, 5HT1B, and 5HT1D receptor activity | SMITHKLINE BEECHAM, PLC | 2005-10-27 | — | — | US | disclosed |
| EP-1228043-B1 | ISOQUINOLINE AND QUINAZOLINE DEIVATIVES HAVING A COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2005-01-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239797-A1 | Isoquinoline and quinazoline derivatives having a combined 5HT1A, 5HT1B, and 5HT1D receptor activity | HTR1B, HTR1A, HTR1D | HTR1A 2/4885HTR1D 3/4885HTR1B 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.