Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | TERT | O14746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6181405 | 0.99 | TGFBR1 (0.57) | TGFBR1CHRNA7ALDH1A1POLBLMNA | |
| SCHEMBL6179924 | 0.92 | TGFBR1 (0.53) | TGFBR1LMNATERTMAPT | |
| SCHEMBL6179278 | 0.92 | TGFBR1 (0.50) | TGFBR1LMNA | |
| SCHEMBL6180800 | 0.91 | TGFBR1 (0.69) | TGFBR1CHRNA7ALDH1A1POLBKMT2A | |
| SCHEMBL373333 | 0.91 | TGFBR1 (0.70) | TGFBR1CHRNA7ALDH1A1KMT2ATSHR | |
| SCHEMBL6180633 | 0.85 | TGFBR1 (0.62) | TGFBR1ALDH1A1LMNATSHRMAPT | |
| SCHEMBL373363 | 0.80 | TGFBR1 (0.69) | TGFBR1HRH3 | |
| SCHEMBL373029 | 0.79 | TGFBR1 (0.66) | TGFBR1 | |
| SCHEMBL6832028 | 0.76 | TGFBR1 (0.54) | TGFBR1HRH3 | |
| SCHEMBL14006002 | 0.76 | CHRNA7 (0.74) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355903-B1 | PYRAZOLE DERIVATIVES AGAINST TGF OVEREXPRESSION | SMITHKLINE BEECHAM CORP (US) | 2005-03-16 | — | — | EP | claimed |