Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 1.00 |
| ▸ | CSF1R | P07333 | 16/20 | 1.00 |
| ▸ | RET | P07949 | 1/20 | 0.69 |
| ▸ | KIF5B | P33176 | 1/20 | 0.69 |
| ▸ | KDR | P35968 | 1/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.68 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6180417 | 0.99 | EGFR (1.00) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL2257706 | 0.82 | CSF1R (1.00) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL6181700 | 0.82 | EGFR (1.00) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL30846509 | 0.82 | EGFR (1.00) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL6839425 | 0.81 | EGFR (0.69) | EGFRCSF1RRETKIF5BKDR | |
| Hydrochloric Acid SCHEMBL6179746 | 0.81 | CSF1R (1.00) | EGFRCSF1RRETKIF5BKDR | |
| Hydrochloric Acid SCHEMBL6180093 | 0.81 | EGFR (1.00) | EGFRCSF1RRETKIF5BKDR | |
| Hydrochloric Acid SCHEMBL6184461 | 0.80 | CSF1R (0.69) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL13951023 | 0.76 | EGFR (0.61) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL6183306 | 0.76 | CSF1R (1.00) | EGFRCSF1RRETKIF5BKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871448-B1 | ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS WHICH INHIBIT CSF-1R RECEPTOR TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2005-03-02 | — | — | EP | claimed |
| US-RE37650-E1 | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase | AVENTIS PHARMACETICAL PRODUCTS, INC. | 2002-04-09 | — | — | US | claimed |
| US-5710158-A | INHIBITORS OF PROTEIN TYROSINE KINASE AND EPIDERMAL GROWTH FACTOR | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-01-20 | — | — | US | claimed |