Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.55 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.55 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.55 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181683 | 0.88 | KCNQ3 (0.50) | KCNQ3KCNQ2KCNE1KCNQ1SMN1; SMN2 | |
| SCHEMBL6179011 | 0.86 | KCNQ3 (0.55) | KCNQ3KCNQ2KCNE1KCNQ1SMN1; SMN2 | |
| SCHEMBL6176384 | 0.85 | KCNQ3 (0.52) | KCNQ3KCNQ2KCNE1KCNQ1SMN1; SMN2 | |
| SCHEMBL6180231 | 0.82 | KCNQ3 (0.53) | KCNQ3KCNQ2KCNE1KCNQ1SMN1; SMN2 | |
| SCHEMBL3146685 | 0.82 | KCNQ3 (0.60) | KCNQ3KCNQ2KCNE1KCNQ1SMN1; SMN2 | |
| SCHEMBL4717167 | 0.82 | KCNQ3 (0.60) | KCNQ3KCNQ2KCNE1KCNQ1KDM4E | |
| SCHEMBL7235460 | 0.82 | KCNQ3 (0.63) | KCNQ3KCNQ2KCNE1KCNQ1KDM4E | |
| Hydrochloric Acid SCHEMBL3140081 | 0.81 | KCNQ3 (0.59) | KCNQ3KCNQ2KCNE1KCNQ1KDM4E | |
| Hydrochloric Acid SCHEMBL3131661 | 0.81 | BCAT2 (0.63) | KCNQ3KCNQ2KCNE1KCNQ1KDM4E | |
| Hydrochloric Acid SCHEMBL3131676 | 0.81 | KCNQ3 (0.59) | KCNQ3KCNQ2KCNE1KCNQ1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066261-B1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2005-11-23 | — | — | EP | disclosed |
| US-6511995-B1 | Inhibits collagen synthesis, which is useful for prophylaxis or treatment of fibrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |