Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | ACACA | Q13085 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10264471 | 0.88 | ACACB (0.56) | ACACBACACATRPA1KMT2A | |
| SCHEMBL12094471 | 0.87 | ACACB (0.53) | ACACBACACALMNATRPA1CHRM2 | |
| SCHEMBL6182576 | 0.86 | ACACB (0.50) | ACACBACACATRPA1PRSS1CTSG | |
| SCHEMBL6182092 | 0.86 | ACACB (0.50) | ACACBACACAPRSS1CTSGCTRB1 | |
| SCHEMBL6181498 | 0.86 | ACACB (0.50) | ACACBACACAPRSS1CTSGCTRB1 | |
| SCHEMBL3283665 | 0.85 | PIN1 (0.40) | PIN1MMP8CYP4F2CYP4A11CCR1 | |
| SCHEMBL6179995 | 0.84 | ACACB (0.47) | ACACBACACALMNATRPA1CHRM2 | |
| SCHEMBL6181940 | 0.84 | ACACB (0.42) | ACACBACACALMNATDP1TRPA1 | |
| SCHEMBL6181978 | 0.83 | ACACB (0.46) | ACACBACACATRPA1PRSS1CTSG | |
| SCHEMBL6180359 | 0.81 | ACACB (0.44) | ACACBACACATDP1TRPA1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597223-A2 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | Esperion Therapeutics Inc. (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004067489-A2 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS, INC. (US) | 2004-08-12 | — | — | WO | disclosed |