Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 10/20 | 0.53 |
| ▸ | PTGER3 | P43115 | 10/20 | 0.53 |
| ▸ | PTGER1 | P34995 | 9/20 | 0.53 |
| ▸ | PTGER2 | P43116 | 9/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6188166 | 0.91 | PTGER4 (0.52) | PTGER4PTGER3PTGER1PTGER2FFAR1 | |
| SCHEMBL6187276 | 0.85 | HRH1 (0.45) | — | |
| SCHEMBL6187858 | 0.83 | TDP1 (0.45) | TDP1L3MBTL1CASP3 | |
| SCHEMBL6185286 | 0.81 | HRH1 (0.46) | — | |
| SCHEMBL6185364 | 0.80 | KDM4E (0.46) | — | |
| SCHEMBL6184768 | 0.79 | TSHR (0.44) | PTGER4PTGER3PTGER1PTGER2FFAR4 | |
| SCHEMBL6186189 | 0.79 | HRH1 (0.45) | DRD2 | |
| SCHEMBL6185121 | 0.79 | ABCB1 (0.49) | L3MBTL1DRD2 | |
| SCHEMBL6182314 | 0.78 | TSHR (0.45) | PTGER4PTGER3PTGER1PTGER2FFAR1 | |
| SCHEMBL6187569 | 0.78 | HRH1 (0.53) | THRADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275641-B1 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-01-12 | — | — | EP | disclosed |
| US-6541471-B1 | Useful as a TXA2 receptor antagonist and a 5-HT2 receptor antagonist | LES LABORATOIRES SERVIER (FR) | 2003-04-01 | — | — | US | disclosed |
| EP-1275641-A2 | Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |