Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 1/20 | 0.63 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651168 | 0.86 | HSPB1 (0.72) | HSPB1MAPTNPSR1RAB9AL3MBTL1 | |
| SCHEMBL3133445 | 0.84 | HSPB1 (0.66) | HSPB1SRD5A2MAPTNPSR1RAB9A | |
| SCHEMBL22530046 | 0.83 | HSPB1 (0.69) | HSPB1MAPTNPSR1RAB9AL3MBTL1 | |
| SCHEMBL29349914 | 0.83 | HSPB1 (0.69) | HSPB1MAPTNPSR1RAB9AL3MBTL1 | |
| SCHEMBL20932230 | 0.83 | HSPB1 (0.82) | HSPB1SRD5A2MAPTNPSR1RAB9A | |
| SCHEMBL1589998 | 0.82 | HSPB1 (0.63) | HSPB1MAPTNPSR1RAB9AL3MBTL1 | |
| SCHEMBL6179474 | 0.81 | HSPB1 (0.61) | HSPB1SRD5A2MAPTNPSR1RAB9A | |
| SCHEMBL10466511 | 0.80 | HSPB1 (0.73) | HSPB1MAPTNPSR1RAB9AL3MBTL1 | |
| SCHEMBL5169540 | 0.80 | HSPB1 (0.57) | HSPB1SRD5A2MAPTNPSR1RAB9A | |
| SCHEMBL5169525 | 0.80 | HSPB1 (0.57) | HSPB1SRD5A2MAPTNPSR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066261-B1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2005-11-23 | — | — | EP | disclosed |
| US-6511995-B1 | Inhibits collagen synthesis, which is useful for prophylaxis or treatment of fibrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-28 | — | — | US | disclosed |
| EP-1066261-A1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048871-A1 | PYRIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-30 | — | — | WO | disclosed |