Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | PPIA | P62937 | 2/20 | 0.41 |
| ▸ | PPIF | P30405 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5578247 | 0.94 | MEN1 (0.56) | CYP19A1MAPTCYP11B1CYP11B2MEN1 | |
| SCHEMBL5578094 | 0.83 | CYP19A1 (0.51) | CYP19A1MAPTCYP11B1CYP11B2MEN1 | |
| SCHEMBL5578104 | 0.83 | CYP19A1 (0.57) | CYP19A1MAPTCYP11B1CYP11B2MEN1 | |
| SCHEMBL1166073 | 0.82 | MAPT (0.54) | MAPTMEN1KMT2ATHRB | |
| SCHEMBL1166659 | 0.81 | ADRA1A (0.45) | CYP19A1MAPTCYP11B1CYP11B2MEN1 | |
| SCHEMBL5578056 | 0.79 | MAPT (0.46) | MAPTKMT2APTGDR2ADRA1AHTR2A | |
| SCHEMBL30363080 | 0.78 | CYP19A1 (0.46) | CYP19A1MAPTCYP11B1CYP11B2MEN1 | |
| SCHEMBL14067176 | 0.77 | PDE5A (0.53) | CYP19A1MAPTHTR2AHTR2C | |
| SCHEMBL1165882 | 0.76 | HTR2A (0.43) | MAPTHTR2AHTR2C | |
| SCHEMBL322593 | 0.76 | LRRK2 (0.51) | MEN1KMT2ALRRK2PTGER1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558582-A1 | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2005012254-A1 | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERTO | ARENA PHARMACEUTICALS, INC. (US) | 2005-02-10 | — | — | WO | disclosed |