Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 14/20 | 0.51 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1473863 | 0.87 | IMPDH2 (0.51) | IMPDH2IMPDH1 | |
| SCHEMBL1474001 | 0.87 | IMPDH2 (0.51) | IMPDH2IMPDH1 | |
| SCHEMBL1473012 | 0.86 | IMPDH2 (0.50) | IMPDH2IMPDH1 | |
| SCHEMBL1474110 | 0.84 | IMPDH2 (0.42) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1472717 | 0.82 | IMPDH2 (0.50) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1473433 | 0.82 | IMPDH2 (0.49) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1472951 | 0.82 | IMPDH2 (0.49) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1473137 | 0.81 | IMPDH2 (0.50) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1475193 | 0.80 | IMPDH2 (0.47) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1472846 | 0.80 | IMPDH2 (0.49) | IMPDH2IMPDH1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1126843-A4 | COMPOUNDS DERIVED FROM AN AMINE NUCLEUS THAT ARE INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2005-06-15 | — | — | EP | claimed |
| EP-1126843-A1 | COMPOUNDS DERIVED FROM AN AMINE NUCLEUS THAT ARE INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-08-29 | — | — | EP | claimed |
| WO-2000025780-A1 | COMPOUNDS DERIVED FROM AN AMINE NUCLEUS THAT ARE INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-05-11 | — | — | WO | claimed |