Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | BMP1 | P13497 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 5/20 | 0.38 |
| ▸ | CA1 | P00915 | 5/20 | 0.38 |
| ▸ | CA2 | P00918 | 5/20 | 0.38 |
| ▸ | CA4 | P22748 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1041350 | 0.85 | TEAD1 (0.54) | HCRTR2KEAP1NFE2L2TEAD1KCNA5 | |
| SCHEMBL1040668 | 0.76 | HCRTR2 (0.61) | HCRTR2KEAP1NFE2L2TEAD1ALDH1A1 | |
| SCHEMBL1039017 | 0.72 | TEAD1 (0.55) | HCRTR2KEAP1NFE2L2TEAD1ALDH1A1 | |
| SCHEMBL1038623 | 0.71 | KEAP1 (0.70) | KEAP1NFE2L2 | |
| SCHEMBL1037788 | 0.71 | HCRTR2 (0.47) | HCRTR2KEAP1NFE2L2TEAD1ALDH1A1 | |
| SCHEMBL1038929 | 0.71 | HCRTR2 (0.51) | HCRTR2KEAP1NFE2L2TEAD1ALDH1A1 | |
| SCHEMBL1038639 | 0.70 | HCRTR2 (0.80) | HCRTR2KEAP1NFE2L2TEAD1ALDH1A1 | |
| SCHEMBL8338556 | 0.69 | PTGER1 (0.55) | KEAP1NFE2L2BMP1ALDH1A1CA12 | |
| SCHEMBL1039082 | 0.68 | HCRTR2 (0.58) | HCRTR2KEAP1NFE2L2TEAD1CA12 | |
| SCHEMBL14029253 | 0.68 | HCRTR2 (0.60) | HCRTR2KEAP1NFE2L2TEAD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554239-A2 | SULFONYLAMINO-ACETIC ACID DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004033418-A2 | SULFONYLAMINO-ACETIC DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-04-22 | — | — | WO | disclosed |