Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487183 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2CHRM2CHRM1 | |
| SCHEMBL6181758 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2CHRM2CHRM1 | |
| SCHEMBL7425391 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2CHRM2CHRM1 | |
| SCHEMBL7556352 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2CHRM2CHRM1 | |
| SCHEMBL7559120 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2CHRM2CHRM1 | |
| SCHEMBL7565562 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2CHRM2CHRM1 | |
| SCHEMBL3700523 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2CHRM2CHRM1 | |
| SCHEMBL6184784 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2CHRM2CHRM1 | |
| SCHEMBL24113374 | 0.94 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2CHRM2CHRM1 | |
| SCHEMBL25362467 | 0.94 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187614-A4 | SUBSTITUTED PIPERIDINES AS MELANOCORTIN-4 RECEPTOR AGONISTS | MERCK & CO INC (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1187614-A1 | SUBSTITUTED PIPERIDINES AS MELANOCORTIN-4 RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2002-03-20 | — | — | EP | disclosed |
| US-6350760-B1 | OBESITY, DIABETES, SEXUAL DYSFUNCTION; | MERCK & CO., INC. | 2002-02-26 | — | — | US | disclosed |
| WO-2000074679-A1 | SUBSTITUTED PIPERIDINES AS MELANOCORTIN-4 RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2000-12-14 | — | — | WO | disclosed |