Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 7/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2938640 | 0.84 | IGF1R (0.44) | IGF1R | |
| SCHEMBL2942430 | 0.77 | NISCH (0.43) | NISCHCYP1A2KDM4ESCN9AENPP2 | |
| SCHEMBL2939413 | 0.77 | IGF1R (0.36) | NISCHKITBRAFIGF1RENPP2 | |
| SCHEMBL2939458 | 0.71 | ENPP2 (0.49) | IGF1RENPP2 | |
| SCHEMBL2935795 | 0.71 | IGF1R (0.46) | IGF1RENPP2 | |
| SCHEMBL2939228 | 0.69 | IGF1R (0.55) | IGF1R | |
| SCHEMBL2938633 | 0.68 | IGF1R (0.47) | IGF1RENPP2 | |
| SCHEMBL2939143 | 0.68 | IGF1R (0.69) | IGF1R | |
| SCHEMBL2936521 | 0.68 | IGF1R (0.44) | IGF1R | |
| SCHEMBL2938971 | 0.67 | IGF1R (0.44) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |