Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.55 |
| ▸ | CCR4 | P51679 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6182891 | 0.86 | KDM4E (0.48) | KDM4ECCR4ALDH1A1NFKBIARELA | |
| SCHEMBL5106613 | 0.84 | CCR4 (0.47) | KDM4ECCR4ALDH1A1NFKBIARELA | |
| SCHEMBL6038494 | 0.79 | KMT2A (0.50) | KDM4EALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL6038356 | 0.79 | MEN1 (0.46) | KDM4ECCR4ALDH1A1HTTNPSR1 | |
| SCHEMBL6180658 | 0.78 | CCR4 (0.69) | KDM4ECCR4ALDH1A1NFKBIARELA | |
| SCHEMBL6038732 | 0.77 | KMT2A (0.48) | KDM4EALDH1A1TSHRLMNAHTT | |
| SCHEMBL1733258 | 0.76 | CCR4 (0.66) | CCR4 | |
| SCHEMBL6039048 | 0.76 | MEN1 (0.49) | KDM4EALDH1A1TSHRLMNAHTT | |
| SCHEMBL6038503 | 0.75 | MEN1 (0.47) | KDM4EALDH1A1TSHRLMNAHTT | |
| SCHEMBL1415781 | 0.74 | GAA (0.63) | KDM4ETSHRKMT2ACYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458715-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-07 | — | — | EP | disclosed |