SCHEMBL6184375

SCHEMBL6184375

CSc1c(C(=O)Cl)ccc2c1OC(F)(F)O2

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 1/20 0.31
WNT3A P56704 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6181865 0.87 CTNNB1 (0.35) CTNNB1WNT3A
Hydrochloric Acid SCHEMBL6184377 0.85 CTNNB1 (0.34) CTNNB1WNT3A
SCHEMBL6182187 0.76 IDO1 (0.32) CTNNB1WNT3A
SCHEMBL6182430 0.76 AR (0.31)
SCHEMBL1256244 0.73 ALOX15 (0.40) CTNNB1WNT3A
SCHEMBL6183667 0.73 AOC3 (0.39)
SCHEMBL6184313 0.73 KDM4E (0.38) CTNNB1WNT3A
SCHEMBL7815894 0.72 SCN9A (0.35) CTNNB1WNT3A
SCHEMBL6181368 0.72 DHODH (0.34)
SCHEMBL6182834 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1160244-B1 Isoxazole derivatives and their use as herbicides BAYER AGRICULTURE LTD (GB) 2005-10-19 EP disclosed
EP-1160244-A1 Isoxazole derivatives and their use as herbicides RHONE-POULENC AGRICULTURE LIMITED (GB) 2001-12-05 EP disclosed
US-5489570-A PRE- OR POST-EMERGENCE RHONE-POULENC AGRICULTURE LIMITED (GB) 1996-02-06 US disclosed
WO-1995025099-A1 2-CYANO-1,3-DIONE DERIVATIVES USEFUL AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1995-09-21 WO disclosed
EP-0636622-A1 Isoxazole derivatives and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1995-02-01 EP disclosed