Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18105807 | 0.86 | ALDH1A1 (0.47) | ALDH1A1LMNAKMT2ACA1CA2 | |
| SCHEMBL18095239 | 0.86 | ALDH1A1 (0.47) | ALDH1A1LMNAKMT2ACA1CA2 | |
| SCHEMBL1982031 | 0.83 | HTT (0.50) | ALDH1A1CA1CA2CA9TSHR | |
| SCHEMBL6669086 | 0.81 | ALDH1A1 (0.62) | ALDH1A1LMNAKMT2ACA1CA2 | |
| SCHEMBL3150175 | 0.81 | ALDH1A1 (0.62) | ALDH1A1LMNAKMT2ACA1CA2 | |
| SCHEMBL15461583 | 0.80 | ALDH1A1 (0.57) | ALDH1A1LMNAKMT2ACA1CA2 | |
| SCHEMBL18095230 | 0.80 | ALDH1A1 (0.54) | ALDH1A1LMNAKMT2ACA1CA2 | |
| SCHEMBL3993683 | 0.79 | PTPN1 (0.46) | ALDH1A1LMNATSHRHSD17B10KDM4E | |
| SCHEMBL5273095 | 0.78 | CYP1A2 (0.41) | ALDH1A1LMNAKMT2ACA1CA2 | |
| SCHEMBL7646202 | 0.78 | ALDH1A1 (0.63) | ALDH1A1LMNAKMT2ATSHRCFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050619-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-06-17 | — | — | WO | disclosed |