Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | NT5E | P21589 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184499 | 0.94 | MAPK14 (0.44) | KCNMA1TGFBR1NT5ENPC1KDM4E | |
| SCHEMBL6183056 | 0.91 | MAPK14 (0.43) | KCNMA1TGFBR1NT5ENPC1L3MBTL1 | |
| SCHEMBL6184681 | 0.91 | NT5E (0.42) | KCNMA1TGFBR1NT5EMAPK14CHEK2 | |
| SCHEMBL6185563 | 0.83 | MAPK14 (0.43) | NT5ENPC1KDM4EL3MBTL1MAPK14 | |
| SCHEMBL6186458 | 0.83 | NT5E (0.43) | TGFBR1NT5EL3MBTL1MAPK14 | |
| SCHEMBL6182069 | 0.82 | NT5E (0.41) | NT5ENPC1L3MBTL1MAPK14ALDH1A1 | |
| SCHEMBL6186115 | 0.81 | NT5E (0.42) | TGFBR1NT5EMAPK14 | |
| SCHEMBL6188438 | 0.80 | MAPK14 (0.45) | NT5EMAPK14MEN1KMT2A | |
| SCHEMBL6184293 | 0.79 | NT5E (0.41) | TGFBR1NT5EKDM4EL3MBTL1MAPK14 | |
| SCHEMBL6182974 | 0.79 | MAPK14 (0.41) | KCNMA1TGFBR1MAPK14GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1247810-B1 | Novel benzotriazoles anti-inflammatory compounds | PFIZER PROD INC (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1247810-A1 | Novel benzotriazoles anti-inflammatory compounds | Pfizer Products Inc. (US) | 2002-10-09 | — | — | EP | disclosed |