Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 4/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RPA1 | P27694 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185563 | 0.93 | MAPK14 (0.43) | NT5EMAPK14CSNK1DCSNK1EPDE10A | |
| SCHEMBL6183056 | 0.92 | MAPK14 (0.43) | NT5EMAPK14CSNK1DCSNK1EPDE10A | |
| SCHEMBL6188438 | 0.90 | MAPK14 (0.45) | NT5EMAPK14CSNK1DCSNK1EPDE10A | |
| SCHEMBL6186115 | 0.90 | NT5E (0.42) | NT5EMAPK14PIN1TP53 | |
| SCHEMBL6183189 | 0.84 | MAPK14 (0.40) | NT5EMAPK14CSNK1DCSNK1ELMNA | |
| SCHEMBL6184613 | 0.82 | KCNMA1 (0.43) | NT5EMAPK14NPC1ALDH1A1RAB9A | |
| SCHEMBL6186458 | 0.82 | NT5E (0.43) | NT5EMAPK14PIN1L3MBTL1 | |
| SCHEMBL6184681 | 0.80 | NT5E (0.42) | NT5EMAPK14 | |
| SCHEMBL6184293 | 0.80 | NT5E (0.41) | NT5EMAPK14LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6182974 | 0.79 | MAPK14 (0.41) | MAPK14CSNK1DCSNK1EPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1247810-B1 | Novel benzotriazoles anti-inflammatory compounds | PFIZER PROD INC (US) | 2005-09-07 | — | — | EP | disclosed |
| US-6664395-B2 | Benzotriazole compoundsn are the potent inhibitors of MAP kinases, preferably p38 kinase. They are useful for treating inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion, ischemia | PFIZER INC | 2003-12-16 | — | — | US | disclosed |
| US-20030078432-A1 | Novel benzotriazoles anti-inflammatory compounds | PFIZER INC. | 2003-04-24 | — | — | US | disclosed |
| EP-1247810-A1 | Novel benzotriazoles anti-inflammatory compounds | Pfizer Products Inc. (US) | 2002-10-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078432-A1 | Novel benzotriazoles anti-inflammatory compounds | MAPK1, JAK1, RUNX1 | NT5E 4156/4885MAPK14 27/4885CSNK1D 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.