SCHEMBL6184733

SCHEMBL6184733

CSc1ccc(C(=O)CC(=O)C2CC2)c2c1OC(F)(F)O2

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.33
HPGD P15428 2/20 0.31
GAA P10253 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6182187 0.81 IDO1 (0.32)
SCHEMBL6181148 0.76 FFAR4 (0.39)
SCHEMBL6183181 0.76 MCL1 (0.33)
SCHEMBL8308747 0.75 HSD17B10 (0.33) HSD17B10HPGD
SCHEMBL8310642 0.75 HSD17B10 (0.33) HSD17B10HPGD
SCHEMBL6182430 0.74 AR (0.31)
SCHEMBL6180678 0.73
SCHEMBL9241917 0.73
SCHEMBL9073271 0.72 MAPT (0.35) HSD17B10HPGDGAAMAPT
SCHEMBL6182417 0.71 SCN9A (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1160244-B1 Isoxazole derivatives and their use as herbicides BAYER AGRICULTURE LTD (GB) 2005-10-19 EP disclosed
EP-0636622-B1 Isoxazole derivatives and their use as herbicides AVENTIS AGRICULTURE LTD (GB) 2002-10-23 EP disclosed
US-5489570-A PRE- OR POST-EMERGENCE RHONE-POULENC AGRICULTURE LIMITED (GB) 1996-02-06 US disclosed
EP-0636622-A1 Isoxazole derivatives and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1995-02-01 EP disclosed