Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 19/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 18/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.68 |
| ▸ | NOS3 | P29474 | 1/20 | 0.58 |
| ▸ | NOS1 | P29475 | 1/20 | 0.58 |
| ▸ | NOS2 | P35228 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5996381 | 0.89 | SLC6A2 (0.73) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| Fumaric Acid SCHEMBL5996389 | 0.89 | SLC6A2 (0.73) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5995080 | 0.89 | SLC6A4 (0.85) | SLC6A2SLC6A4SLC6A3CYP2D6NOS3 | |
| SCHEMBL4498479 | 0.85 | SLC6A2 (0.72) | SLC6A2SLC6A4SLC6A3CYP2D6NOS3 | |
| SCHEMBL5995382 | 0.83 | NOS3 (0.70) | SLC6A2SLC6A4SLC6A3CYP2D6NOS3 | |
| SCHEMBL5996423 | 0.83 | SLC6A4 (0.69) | SLC6A2SLC6A4SLC6A3CYP2D6NOS3 | |
| SCHEMBL5997056 | 0.82 | SLC6A2 (0.70) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL5995191 | 0.81 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5995218 | 0.81 | SLC6A2 (0.64) | SLC6A2SLC6A4SLC6A3CYP2D6NOS3 | |
| SCHEMBL5996571 | 0.81 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569905-A2 | INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004052858-A2 | INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2004-06-24 | — | — | WO | disclosed |