Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SORD | Q00796 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6183115 | 0.86 | MAPT (0.44) | KDM4EPOLBDRD4DRD2SLC6A7 | |
| SCHEMBL4813430 | 0.75 | NAMPT (0.49) | KDM4EPOLBDRD4DRD2SLC6A7 | |
| SCHEMBL1462353 | 0.65 | IGF1R (0.55) | KDM4EPOLBDRD4DRD2SORD | |
| SCHEMBL11082813 | 0.65 | GFER (0.57) | KDM4EPOLBSLC6A7 | |
| SCHEMBL11083771 | 0.64 | HRH3 (0.62) | DRD4DRD2HRH3DRD3 | |
| SCHEMBL5755134 | 0.64 | GFER (0.44) | KDM4EPOLBDRD4DRD2SLC6A7 | |
| SCHEMBL4808795 | 0.64 | GFER (0.43) | KDM4EPOLBDRD4DRD2SLC6A7 | |
| SCHEMBL10968173 | 0.62 | TRPV1 (0.67) | KDM4E | |
| SCHEMBL5760744 | 0.62 | KMT2A (0.49) | KDM4EPOLBDRD4DRD2SLC6A7 | |
| SCHEMBL31029146 | 0.61 | KDM4E (0.48) | KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513835-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003104225-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2003-12-18 | — | — | WO | disclosed |