Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184871 | 0.86 | KDM4E (0.44) | DRD2DRD3DRD4KDM4EPOLB | |
| SCHEMBL4807294 | 0.78 | MAPT (0.46) | MAPTLMNAALDH1A1GAADRD2 | |
| SCHEMBL5759230 | 0.74 | ALDH1A1 (0.43) | MAPTLMNAALDH1A1DRD4TSHR | |
| SCHEMBL186236 | 0.69 | TRPV1 (0.39) | MAPTLMNAALDH1A1GAAP2RX7 | |
| SCHEMBL4814062 | 0.65 | ALDH1A1 (0.48) | MAPTLMNAALDH1A1GAATSHR | |
| SCHEMBL3775676 | 0.63 | MAPT (0.47) | MAPTLMNAALDH1A1GAATP53 | |
| SCHEMBL4813430 | 0.62 | NAMPT (0.49) | DRD2DRD4KDM4EPOLBSLC6A7 | |
| SCHEMBL4812798 | 0.62 | JAK1 (0.41) | MAPTLMNAALDH1A1GAADRD4 | |
| SCHEMBL10528092 | 0.61 | FDPS (0.36) | — | |
| SCHEMBL4815951 | 0.61 | SLC6A7 (0.41) | MAPTLMNAALDH1A1GAADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513835-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003104225-A1 | PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2003-12-18 | — | — | WO | disclosed |