Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.62 |
| ▸ | CDK1 | P06493 | 8/20 | 0.62 |
| ▸ | ABL1 | P00519 | 8/20 | 0.62 |
| ▸ | PRKCA | P17252 | 6/20 | 0.62 |
| ▸ | SRC | P12931 | 6/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.49 |
| ▸ | ABL2 | P42684 | 2/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8122065 | 0.90 | EGFR (0.66) | EGFRCDK1ABL1PRKCASRC | |
| SCHEMBL6186191 | 0.89 | EGFR (0.67) | EGFRCDK1ABL1PRKCASRC | |
| SCHEMBL8577275 | 0.88 | EGFR (0.63) | EGFRCDK1ABL1PRKCASRC | |
| SCHEMBL6190120 | 0.87 | EGFR (0.62) | EGFRCDK1ABL1PRKCASRC | |
| SCHEMBL6187136 | 0.86 | EGFR (0.61) | EGFRCDK1ABL1PRKCASRC | |
| SCHEMBL8581909 | 0.86 | EGFR (0.60) | EGFRCDK1ABL1PRKCASRC | |
| SCHEMBL6188768 | 0.86 | EGFR (0.63) | EGFRCDK1ABL1PRKCASRC | |
| SCHEMBL8577296 | 0.85 | EGFR (0.68) | EGFRCDK1ABL1PRKCASRC | |
| SCHEMBL6186002 | 0.85 | EGFR (0.61) | EGFRCDK1ABL1PRKCASRC | |
| SCHEMBL6189076 | 0.85 | EGFR (0.59) | EGFRCDK1ABL1PRKCASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929553-B1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2005-03-16 | — | — | EP | disclosed |
| US-6251911-B1 | Pyrimidine derivatives and processes for the preparation thereof | NOVARTIS AG (CH) | 2001-06-26 | — | — | US | disclosed |
| EP-0929553-A1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998014450-A1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1998-04-09 | — | — | WO | disclosed |