Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.68 |
| ▸ | ABL1 | P00519 | 8/20 | 0.68 |
| ▸ | CDK1 | P06493 | 7/20 | 0.68 |
| ▸ | PRKCA | P17252 | 4/20 | 0.68 |
| ▸ | SRC | P12931 | 5/20 | 0.61 |
| ▸ | ABL2 | P42684 | 1/20 | 0.48 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6186191 | 0.89 | EGFR (0.67) | EGFRABL1CDK1PRKCASRC | |
| SCHEMBL8122065 | 0.88 | EGFR (0.66) | EGFRABL1CDK1PRKCASRC | |
| SCHEMBL6189215 | 0.86 | EGFR (0.64) | EGFRABL1CDK1PRKCASRC | |
| SCHEMBL8577275 | 0.86 | EGFR (0.63) | EGFRABL1CDK1PRKCASRC | |
| SCHEMBL6190120 | 0.85 | EGFR (0.62) | EGFRABL1CDK1PRKCASRC | |
| SCHEMBL6184979 | 0.85 | EGFR (0.62) | EGFRABL1CDK1PRKCASRC | |
| SCHEMBL6190406 | 0.85 | EGFR (0.67) | EGFRABL1CDK1PRKCASRC | |
| SCHEMBL6187136 | 0.85 | EGFR (0.61) | EGFRABL1CDK1PRKCASRC | |
| SCHEMBL6187995 | 0.85 | EGFR (0.66) | EGFRABL1CDK1PRKCASRC | |
| SCHEMBL6187645 | 0.84 | EGFR (0.66) | EGFRABL1CDK1PRKCASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998014449-A1 | FUSED PYRAZOLE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1998-04-09 | — | — | WO | claimed |