Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 4/20 | 0.35 |
| ▸ | HPD | P32754 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9289119 | 0.94 | MLNR (0.37) | KMT2ASMN1; SMN2NAAAALOX5ADAM17 | |
| SCHEMBL9283987 | 0.89 | HPD (0.33) | KMT2ASMN1; SMN2NAAAMAOBBCHE | |
| SCHEMBL6175094 | 0.89 | SMN1; SMN2 (0.36) | KMT2ASMN1; SMN2NAAAALOX5ADAM17 | |
| SCHEMBL6175689 | 0.85 | EGFR (0.36) | KMT2AMEN1 | |
| SCHEMBL6175466 | 0.80 | SMN1; SMN2 (0.39) | KMT2ASMN1; SMN2NAAAADAM17MAOB | |
| SCHEMBL9195529 | 0.79 | SMN1; SMN2 (0.36) | KMT2ASMN1; SMN2NAAAALOX5ADAM17 | |
| SCHEMBL27431263 | 0.79 | EGFR (0.36) | — | |
| SCHEMBL6174313 | 0.77 | EGFR (0.37) | KMT2AMEN1 | |
| SCHEMBL6175098 | 0.76 | MAOB (0.40) | KMT2ANAAAADAM17MAOBMEN1 | |
| SCHEMBL6175092 | 0.76 | MAOB (0.40) | KMT2ANAAAADAM17MAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-B1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | UPJOHN CO (US) | 2005-03-09 | — | — | EP | disclosed |
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1203770-A1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | PHARMACIA & UPJOHN COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |