Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 1.00 |
| ▸ | CSF1R | P07333 | 1/20 | 0.98 |
| ▸ | KIT | P10721 | 2/20 | 0.72 |
| ▸ | RET | P07949 | 2/20 | 0.69 |
| ▸ | KIF5B | P33176 | 1/20 | 0.69 |
| ▸ | KDR | P35968 | 1/20 | 0.69 |
| ▸ | ACHE | P22303 | 6/20 | 0.58 |
| ▸ | BACE1 | P56817 | 6/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6179838 | 0.99 | EGFR (1.00) | EGFRCSF1RKITRETKIF5B | |
| SCHEMBL4719788 | 0.93 | EGFR (0.87) | EGFRCSF1RKITRETKIF5B | |
| SCHEMBL4717907 | 0.92 | EGFR (0.85) | EGFRCSF1RKITRETKIF5B | |
| Hydrochloric Acid SCHEMBL6180077 | 0.92 | EGFR (0.87) | EGFRCSF1RKITRETKIF5B | |
| SCHEMBL9112738 | 0.91 | EGFR (0.83) | EGFRCSF1RKITRETKIF5B | |
| SCHEMBL8648433 | 0.87 | EGFR (0.76) | EGFRCSF1RKITRETKIF5B | |
| SCHEMBL8646304 | 0.86 | EGFR (0.75) | EGFRCSF1RKITRETKIF5B | |
| SCHEMBL8652258 | 0.86 | EGFR (0.75) | EGFRCSF1RKITRETKIF5B | |
| SCHEMBL9052748 | 0.86 | EGFR (0.75) | EGFRCSF1RKITRETKIF5B | |
| SCHEMBL9115430 | 0.86 | EGFR (0.75) | EGFRCSF1RKITRETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871448-B1 | ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS WHICH INHIBIT CSF-1R RECEPTOR TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2005-03-02 | — | — | EP | claimed |
| US-RE37650-E1 | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase | AVENTIS PHARMACETICAL PRODUCTS, INC. | 2002-04-09 | — | — | US | claimed |
| US-5710158-A | INHIBITORS OF PROTEIN TYROSINE KINASE AND EPIDERMAL GROWTH FACTOR | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-01-20 | — | — | US | claimed |
| CN-1100540-C | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties | AVENTIS PHARMA INC (US) | 2003-02-05 | — | — | CN | disclosed |
| CN-1187129-A | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties | RHONE POULENC RORER PHARMA (US) | 1998-07-08 | — | — | CN | disclosed |
| US-5736534-A | HYPERPROLIFERATIVE DISEASES; INHIBITORS OF PROTEIN-TYROSINE KINASES SUCH AS EPIDERMAL GROWTH FACTOR RECEPTOR; BRAIN, LUNG, BREAST CANCER; PSORIASIS AND BENIGN PROSTATE HYPERPLASIA | PFIZER INC. (US) | 1998-04-07 | — | — | US | disclosed |
| WO-1995023141-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1995-08-31 | — | — | WO | disclosed |