Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.75 |
| ▸ | CSF1R | P07333 | 1/20 | 0.73 |
| ▸ | RET | P07949 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | KIF5B | P33176 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 3/20 | 0.56 |
| ▸ | ACHE | P22303 | 6/20 | 0.54 |
| ▸ | BACE1 | P56817 | 6/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
| ▸ | TUBB | P07437 | 1/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8649920 | 0.99 | EGFR (0.76) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL8644637 | 0.91 | EGFR (0.75) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL8652258 | 0.88 | EGFR (0.75) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL9115430 | 0.88 | EGFR (0.75) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL8647385 | 0.87 | EGFR (0.73) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL8645023 | 0.87 | EGFR (0.73) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL6185124 | 0.86 | EGFR (1.00) | EGFRCSF1RRETKDRKIF5B | |
| Hydrochloric Acid SCHEMBL6179838 | 0.85 | EGFR (1.00) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL9116168 | 0.83 | EGFR (0.67) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL8648530 | 0.83 | EGFR (0.67) | EGFRCSF1RRETKDRKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5736534-A | HYPERPROLIFERATIVE DISEASES; INHIBITORS OF PROTEIN-TYROSINE KINASES SUCH AS EPIDERMAL GROWTH FACTOR RECEPTOR; BRAIN, LUNG, BREAST CANCER; PSORIASIS AND BENIGN PROSTATE HYPERPLASIA | PFIZER INC. (US) | 1998-04-07 | — | — | US | disclosed |
| EP-0746554-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995023141-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1995-08-31 | — | — | WO | disclosed |