Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2734327 | 0.81 | KDM4E (0.52) | KDM4ECLK4NTRK1LTKTYRO3 | |
| SCHEMBL11823 | 0.79 | TLR8 (0.58) | KDM4ECLK4NTRK1LTKTYRO3 | |
| Hydrochloric Acid SCHEMBL6623126 | 0.79 | KDM4E (0.51) | KDM4ECLK4NTRK1LTKTYRO3 | |
| SCHEMBL2857719 | 0.78 | MEN1 (0.44) | KDM4ECLK4NTRK1LTKTYRO3 | |
| SCHEMBL1977970 | 0.78 | BACE1 (0.56) | KDM4EPRMT5MAPTNPC1ALDH1A1 | |
| SCHEMBL24463198 | 0.78 | CLK4 (0.41) | KDM4ECLK4NTRK1LTKTYRO3 | |
| SCHEMBL28370090 | 0.78 | CLK4 (0.41) | KDM4ECLK4NTRK1LTKTYRO3 | |
| SCHEMBL16755302 | 0.78 | MAPT (0.53) | KDM4ECLK4NTRK1LTKTYRO3 | |
| SCHEMBL22121309 | 0.76 | HCAR3 (0.54) | KDM4EHPGDHTTHSD17B10TDP1 | |
| SCHEMBL19437535 | 0.76 | KMT2A (0.55) | KDM4ECLK4DAPK3CSNK1A1LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | Chiron Corporation (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003082272-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | CHIRON CORPORATION (US) | 2003-10-09 | — | — | WO | disclosed |