Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | GCK | P35557 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 10/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 10/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.32 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175374 | 0.87 | AKR1C3 (0.38) | KCNH2APPPSEN1PSEN2APH1B | |
| SCHEMBL2645963 | 0.79 | KCNH2 (0.48) | KCNH2GCKAPPPSEN1PSEN2 | |
| SCHEMBL2645781 | 0.79 | KCNH2 (0.48) | KCNH2GCKAPPPSEN1PSEN2 | |
| SCHEMBL2648910 | 0.78 | KCNH2 (0.47) | KCNH2GCKAPPPSEN1PSEN2 | |
| SCHEMBL6172615 | 0.78 | SMURF1 (0.37) | KCNH2GCKAPPSCN9A | |
| SCHEMBL6176230 | 0.76 | KCNH2 (0.43) | KCNH2GCKLMNATP53ALDH1A1 | |
| SCHEMBL2651023 | 0.75 | APP (0.43) | KCNH2GCKAPPPSEN1PSEN2 | |
| SCHEMBL6175104 | 0.75 | KCNH2 (0.34) | KCNH2GCKSCN9A | |
| SCHEMBL6175702 | 0.74 | KCNH2 (0.39) | KCNH2APPPSEN1PSEN2APH1B | |
| SCHEMBL2646133 | 0.73 | AKR1C3 (0.44) | KCNH2APPPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311504-B1 | TETRAZOLYL-PHENYL ACETAMIDE GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2005-06-15 | — | — | EP | disclosed |