Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184734 | 0.88 | GRIN1 (0.40) | L3MBTL1GRIN2BGRIN1SLC6A2MAPT | |
| SCHEMBL2331866 | 0.81 | CHRM2 (0.36) | MAPT | |
| SCHEMBL8349073 | 0.81 | USP2 (0.41) | MAPT | |
| Hydrochloric Acid SCHEMBL11619919 | 0.75 | KMT2A (0.42) | MAPTKDM4E | |
| SCHEMBL6186053 | 0.75 | CYP3A4 (0.41) | — | |
| SCHEMBL5745430 | 0.75 | CYP3A4 (0.41) | — | |
| SCHEMBL6185503 | 0.75 | L3MBTL1 (0.39) | L3MBTL1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL11620280 | 0.74 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL27682123 | 0.74 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL6185575 | 0.73 | NPC1 (0.40) | TP53L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567525-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004052887-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2004-06-24 | — | — | WO | disclosed |