Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15175477 | 0.86 | NR4A2 (0.65) | NR4A2ALOX5KDM4EMEN1KMT2A | |
| SCHEMBL22275928 | 0.86 | NR4A2 (0.65) | NR4A2ALOX5KDM4EMEN1KMT2A | |
| SCHEMBL7461349 | 0.86 | NR4A2 (0.57) | NR4A2ALOX5KDM4EMEN1KMT2A | |
| SCHEMBL14638989 | 0.85 | NR4A2 (0.63) | NR4A2ALOX5KDM4EMEN1KMT2A | |
| SCHEMBL7474876 | 0.84 | NR4A2 (0.61) | NR4A2ALOX5KDM4EMEN1KMT2A | |
| SCHEMBL9358044 | 0.82 | NR4A2 (0.60) | NR4A2ALOX5KDM4EMEN1KMT2A | |
| SCHEMBL9353789 | 0.80 | NR4A2 (0.57) | NR4A2ALOX5KDM4EMEN1KMT2A | |
| SCHEMBL15174192 | 0.80 | NR4A2 (0.69) | NR4A2ALOX5KDM4EMEN1KMT2A | |
| SCHEMBL9353800 | 0.78 | NR4A2 (0.55) | NR4A2ALOX5KDM4EMEN1KMT2A | |
| SCHEMBL6216675 | 0.78 | NR4A2 (1.00) | NR4A2ALOX5KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1505968-A1 | MULTICYCLIC COMPOUNDS FOR USE AS MELANIN CONCENTRATING HORMONE ANTAGONISTS IN THE TREATMENT OF OBESITY AND DIABETES | ELI LILLY AND COMPANY (US) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097047-A1 | MULTICYCLIC COMPOUNDS FOR USE AS MELANIN CONCENTRATING HORMONE ANTAGONISTS IN THE TREATMENT OF OBESITY AND DIABETES | ELI LILLY AND COMPANY (US) | 2003-11-27 | — | — | WO | disclosed |