Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.50 |
| ▸ | GABRP | O00591 | 1/20 | 0.48 |
| ▸ | GABRD | O14764 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15175477 | 0.88 | NR4A2 (0.65) | NR4A2ALOX5MEN1KMT2AALDH1A1 | |
| SCHEMBL22275928 | 0.85 | NR4A2 (0.65) | NR4A2ALOX5MEN1KMT2AALDH1A1 | |
| SCHEMBL9353789 | 0.85 | NR4A2 (0.57) | NR4A2ALOX5MEN1KMT2AALDH1A1 | |
| SCHEMBL7461349 | 0.85 | NR4A2 (0.57) | NR4A2ALOX5MEN1KMT2AALDH1A1 | |
| SCHEMBL6185644 | 0.84 | NR4A2 (0.63) | NR4A2ALOX5MEN1KMT2AALDH1A1 | |
| SCHEMBL14638989 | 0.84 | NR4A2 (0.63) | NR4A2ALOX5MEN1KMT2AALDH1A1 | |
| SCHEMBL14555859 | 0.83 | OXER1 (0.53) | NR4A2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL7551694 | 0.83 | OXER1 (0.60) | KMT2AALDH1A1KDM4EHPGDCHRNB2 | |
| SCHEMBL9353800 | 0.82 | NR4A2 (0.55) | NR4A2ALOX5MEN1KMT2AALDH1A1 | |
| SCHEMBL9358044 | 0.81 | NR4A2 (0.60) | NR4A2ALOX5MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002877-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |