Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 14/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185147 | 0.86 | CCR4 (0.42) | CCR4 | |
| SCHEMBL6185129 | 0.83 | CCR4 (0.37) | CCR4ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6182695 | 0.80 | CCR4 (0.51) | CCR4 | |
| SCHEMBL6183036 | 0.80 | CCR4 (0.34) | CCR4 | |
| SCHEMBL6181633 | 0.76 | KDM4E (0.53) | CCR4POLBALDH1A1KDM4EMAPT | |
| SCHEMBL5103326 | 0.76 | CCR4 (0.48) | CCR4ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL6183754 | 0.74 | CCR4 (0.54) | CCR4 | |
| SCHEMBL6183411 | 0.71 | USP2 (0.35) | CCR4POLBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6180554 | 0.71 | CCR4 (0.51) | CCR4POLBALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL6184819 | 0.70 | CCR4 (0.49) | CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458715-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-07 | — | — | EP | claimed |