Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CCR4 | P51679 | 3/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5103326 | 0.86 | CCR4 (0.48) | KDM4EKMT2AMEN1ALDH1A1CCR4 | |
| SCHEMBL4682218 | 0.84 | KDM4E (0.69) | KDM4EKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL6182891 | 0.81 | KDM4E (0.48) | KDM4EKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL6183896 | 0.80 | CCR4 (0.64) | KDM4EKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL6197275 | 0.79 | CCR4 (0.44) | KDM4EKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL5103019 | 0.77 | CCR4 (0.65) | KDM4EKMT2AMEN1CCR4 | |
| SCHEMBL5617402 | 0.76 | KDM4E (0.54) | KDM4EKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL6185693 | 0.76 | CCR4 (0.37) | KDM4EKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL6182958 | 0.73 | CCR4 (0.74) | KDM4EKMT2AMEN1POLBCCR4 | |
| SCHEMBL5111658 | 0.71 | CCR4 (0.68) | KMT2AMEN1ALDH1A1CCR4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458715-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-07 | — | — | EP | disclosed |