Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | HTR1E | P28566 | 1/20 | 0.55 |
| ▸ | HTR1F | P30939 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6186060 | 0.89 | HTR6 (0.78) | HTR6HTR1AHTR2CHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL6190002 | 0.88 | HTR6 (0.76) | HTR6HTR1AHTR2CHTR7HTR2B | |
| SCHEMBL6186323 | 0.87 | HTR6 (0.59) | HTR6KMT2ACYP1A2CYP3A4HTR1A | |
| SCHEMBL6186465 | 0.86 | HTR6 (0.63) | HTR6KMT2ACYP1A2CYP3A4HTR1A | |
| Hydrochloric Acid SCHEMBL6189541 | 0.86 | HTR6 (0.58) | HTR6KMT2ACYP1A2CYP3A4HTR1A | |
| Hydrochloric Acid SCHEMBL6192130 | 0.85 | HTR6 (0.62) | HTR6KMT2ACYP1A2CYP3A4HTR1A | |
| SCHEMBL6188352 | 0.85 | HTR6 (0.62) | HTR6KMT2ACYP1A2CYP3A4HTR1A | |
| SCHEMBL6186656 | 0.85 | HTR6 (0.64) | HTR6KMT2ACYP1A2CYP3A4HTR1A | |
| Hydrochloric Acid SCHEMBL6186574 | 0.84 | HTR6 (0.61) | HTR6KMT2ACYP1A2CYP3A4HTR1A | |
| SCHEMBL6185729 | 0.84 | HTR6 (0.64) | HTR6KMT2ACYP1A2CYP3A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994862-B1 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | claimed |
| EP-0994862-B1 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | disclosed |
| US-6316450-B1 | PIPERAZINE COMPOUNDS FOR TREATING DEPRESSION AND ANXIETY | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-11-13 | — | — | US | disclosed |